2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140131
    Biotin-PEG4-PC-PEG4-alkyne
    Biotin-PEG4-PC-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-PC-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG4-PC-PEG4-alkyne
  • HY-143815
    m-PEG18-acid
    m-PEG18-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG18-acid
  • HY-130891
    (+)-Biotin-PEG6-hydrazide 2601437-70-9
    (+)-Biotin-PEG6-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (+)-Biotin-PEG6-hydrazide
  • HY-168249
    trans-4-(2-Chloropyrimidin-5-yl)cyclohexanecarboxylic acid
    trans-4-(2-Chloropyrimidin-5-yl)cyclohexanecarboxylic acid is a PROTAC Linker that can be used to synthesize PROTAC BRM/BRG1 degrader-2 (HY-168247).
    trans-4-(2-Chloropyrimidin-5-yl)cyclohexanecarboxylic acid
  • HY-145247
    Biotin-PEG7-C2-S-Vidarabine
    Biotin-PEG7-C2-S-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses.
    Biotin-PEG7-C2-S-Vidarabine
  • HY-159592
    Piperazine-Pyrimidine-Cyclohexane-COOEt
    Piperazine-Pyrimidine-Cyclohexane-COOEt is a PROTAC linker. Piperazine-Pyrimidine-Cyclohexane-COOEt can be used in the synthesis of PROTAC SMARCA2/4-degrader-1 (HY-159452).
    Piperazine-Pyrimidine-Cyclohexane-COOEt
  • HY-169236
    COOH-C-PEG2-NHCO-C2-COOH 947504-71-4
    COOH-C-PEG2-NHCO-C2-COOH is a PROTAC linker that is used to synthesize PCC16 chloride (HY-169232).
    COOH-C-PEG2-NHCO-C2-COOH
  • HY-140763
    Azido-PEG1-CH2CO2-NHS 1480545-09-2
    Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-CH2CO2-NHS
  • HY-141348
    S-acetyl-PEG6-Boc 1818294-39-1
    S-acetyl-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG6-Boc
  • HY-134684
    Mal-PEG3-O-Ac
    Mal-PEG3-O-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG3-O-Ac
  • HY-W096132
    Dimethylamino-PEG2-C2-NH2 692782-62-0
    Dimethylamino-PEG2-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dimethylamino-PEG2-C2-NH2
  • HY-141019
    Bis-PEG11-acid 2097010-30-3
    Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG11-acid
  • HY-140881
    Boc-NH-PEG6-propargyl 1262991-52-5
    Boc-NH-PEG6-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG6-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-NH-PEG6-propargyl
  • HY-132072
    THP-PEG8-THP
    THP-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG8-THP
  • HY-140052
    Boc-aminooxy-PEG4-propargyl 1895922-77-6
    Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-aminooxy-PEG4-propargyl
  • HY-133501
    Boc-HyNic-PEG2-N3
    Boc-HyNic-PEG2-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-HyNic-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-HyNic-PEG2-N3
  • HY-133702
    Aniline-piperazine-C3-NH-Boc 643087-19-8
    Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor).
    Aniline-piperazine-C3-NH-Boc
  • HY-141173
    TCO-PEG8-TFP ester 2353410-06-5
    TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-PEG8-TFP ester
  • HY-141398
    m-PEG9-t-Butyl ester 2768015-30-9
    m-PEG9-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG9-t-Butyl ester
  • HY-141041
    N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 2107273-42-5
    N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5
PROTAC Linkers Isoform Comparison

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